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Image in Critical Care
Pulmonary
A Pleural Catheter Malposition through Diaphragm to Abdominal Cavity
Won Jai Jung, Sue In Choi, Eun Joo Lee, Sang Yeub Lee, Kwang Ho In
Korean J Crit Care Med. 2017;32(4):370-371.   Published online November 30, 2017
DOI: https://doi.org/10.4266/kjccm.2017.00290
  • 5,498 View
  • 119 Download
  • 2 Web of Science
  • 1 Crossref
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Citations to this article as recorded by  
  • The Malpositioned Tunneled Pleural Catheter
    Olaedo Abana, Uzair Ghori, Ammar Alqaid, Robert Holladay
    Journal of Bronchology & Interventional Pulmonology.2021; 28(4): e62.     CrossRef
Original Article
Infection
Implications of Plasma Renin Activity and Plasma Aldosterone Concentration in Critically Ill Patients with Septic Shock
Kyung Soo Chung, Joo Han Song, Won Jai Jung, Young Sam Kim, Se Kyu Kim, Joon Chang, Moo Suk Park
Korean J Crit Care Med. 2017;32(2):142-153.   Published online May 31, 2017
DOI: https://doi.org/10.4266/kjccm.2017.00094
  • 8,480 View
  • 215 Download
  • 12 Web of Science
  • 15 Crossref
AbstractAbstract PDFSupplementary Material
Background
The renin-angiotensin-aldosterone system is closely associated with volume status and vascular tone in septic shock. The present study aimed to assess whether plasma renin activity (PRA) and plasma aldosterone concentration (PAC) measurements compared with conventional severity indicators are associated with mortality in patients with septic shock.
Methods
We evaluated 105 patients who were admitted for septic shock. Plasma levels of the biomarkers PRA and PAC, the PAC/PRA ratio, C-reactive protein (CRP) level, and cortisol level on days 1, 3, and 7 were serially measured. During the intensive care unit stay, relevant clinical information and laboratory results were recorded.
Results
Patients were divided into two groups according to 28-day mortality: survivors (n = 59) and non-survivors (n = 46). The survivor group showed lower PRA, PAC, Acute Physiologic and Chronic Health Evaluation (APACHE) II score, and Sequential Organ Failure Assessment (SOFA) score than did the non-survivor group (all P < 0.05). The SOFA score was positively correlated with PRA (r = 0.373, P < 0.001) and PAC (r = 0.316, P = 0.001). According to receiver operating characteristic analysis, the areas under the curve of PRA and PAC to predict 28-day mortality were 0.69 (95% confidence interval [CI], 0.58 to 0.79; P = 0.001) and 0.67 (95% CI, 0.56 to 0.77; P = 0.003), respectively, similar to the APACHE II scores and SOFA scores. In particular, the group with PRA value ≥3.5 ng ml-1 h-1 on day 1 showed significantly greater mortality than did the group with PRA value <3.5 ng ml-1 h-1 (log-rank test, P < 0.001). According to multivariate analysis, SOFA score (hazard ratio, 1.11; 95% CI, 1.01 to 1.22), PRA value ≥3.5 ng ml-1 h-1 (hazard ratio, 3.25; 95% CI, 1.60 to 6.60), previous history of cancer (hazard ratio, 3.44; 95% CI, 1.72 to 6.90), and coronary arterial occlusive disease (hazard ratio, 2.99; 95% CI, 1.26 to 7.08) were predictors of 28-day mortality.
Conclusions
Elevated PRA is a useful biomarker to stratify the risk of critically ill patients with septic shock and is a prognostic predictor of 28-day mortality.

Citations

Citations to this article as recorded by  
  • Association of Active Renin Content With Mortality in Critically Ill Patients: A Post hoc Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) Trial*
    Laurence W. Busse, Christopher L. Schaich, Mark C. Chappell, Michael T. McCurdy, Erin M. Staples, Caitlin C. Ten Lohuis, Jeremiah S. Hinson, Jonathan E. Sevransky, Richard E. Rothman, David W. Wright, Greg S. Martin, Ashish K. Khanna
    Critical Care Medicine.2024; 52(3): 441.     CrossRef
  • Renin as a Prognostic Marker in Intensive Care and Perioperative Settings: A Scoping Review
    Yuki Kotani, Alessandro Belletti, Giacomo Maiucci, Martina Lodovici, Stefano Fresilli, Giovanni Landoni, Rinaldo Bellomo, Alexander Zarbock
    Anesthesia & Analgesia.2024; 138(5): 929.     CrossRef
  • Renin as a Prognostic and Predictive Biomarker in Sepsis: More Questions Than Answers?*
    Emily J. See, James A. Russell, Rinaldo Bellomo, Patrick R. Lawler
    Critical Care Medicine.2024; 52(3): 509.     CrossRef
  • Dysfunction of the renin-angiotensin-aldosterone system in human septic shock
    Christopher L. Schaich, Daniel E. Leisman, Marcia B. Goldberg, Micheal R. Filbin, Ashish K. Khanna, Mark C. Chappell
    Peptides.2024; 176: 171201.     CrossRef
  • Blood urea nitrogen - independent marker of mortality in sepsis
    Martin Harazim, Kaiquan Tan, Marek Nalos, Martin Matejovic
    Biomedical Papers.2023; 167(1): 24.     CrossRef
  • Critically ill children with septic shock: time to rediscover renin?
    Isabella Guzzo, Fabio Paglialonga
    Pediatric Nephrology.2023; 38(9): 2907.     CrossRef
  • The role of proadrenomedullin, interleukin 6 and CD64 in the diagnosis and prognosis of septic shock
    Yasemin Bozkurt Turan
    BMC Anesthesiology.2023;[Epub]     CrossRef
  • Renin Kinetics Are Superior to Lactate Kinetics for Predicting In-Hospital Mortality in Hypotensive Critically Ill Patients*
    Maniraj Jeyaraju, Michael T. McCurdy, Andrea R. Levine, Prasad Devarajan, Michael A. Mazzeffi, Kristin E. Mullins, Michaella Reif, David N. Yim, Christopher Parrino, Allison S. Lankford, Jonathan H. Chow
    Critical Care Medicine.2022; 50(1): 50.     CrossRef
  • Mechanisms of Post-critical Illness Cardiovascular Disease
    Andrew Owen, Jaimin M. Patel, Dhruv Parekh, Mansoor N. Bangash
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Renin as a Marker of Tissue Perfusion, Septic Shock and Mortality in Septic Patients: A Prospective Observational Study
    Patrycja Leśnik, Lidia Łysenko, Małgorzata Krzystek-Korpacka, Ewa Woźnica-Niesobska, Magdalena Mierzchała-Pasierb, Jarosław Janc
    International Journal of Molecular Sciences.2022; 23(16): 9133.     CrossRef
  • Angiotensin II and Vasopressin for Vasodilatory Shock: A Critical Appraisal of Catecholamine-Sparing Strategies
    Mojdeh S. Heavner, Michael T. McCurdy, Michael A. Mazzeffi, Samuel M. Galvagno, Kenichi A. Tanaka, Jonathan H. Chow
    Journal of Intensive Care Medicine.2021; 36(6): 635.     CrossRef
  • Treatment of Renin-Angiotensin-Aldosterone System Dysfunction With Angiotensin II in High-Renin Septic Shock
    Jonathan H. Chow, Marianne Wallis, Allison S. Lankford, Zackary Chancer, Rolf N. Barth, Joseph R. Scalea, John C. LaMattina, Michael A. Mazzeffi, Michael T. McCurdy
    Seminars in Cardiothoracic and Vascular Anesthesia.2021; 25(1): 67.     CrossRef
  • Good clinical practice for the use of vasopressor and inotropic drugs in critically ill patients: state-of-the-art and expert consensus
    Andrea CARSETTI, Elena BIGNAMI, Andrea CORTEGIANI, Katia DONADELLO, Abele DONATI, Giuseppe FOTI, Giacomo GRASSELLI, Stefano ROMAGNOLI, Massimo ANTONELLI, Elvio DE BLASIO, Francesco FORFORI, Fabio GUARRACINO, Sabino SCOLLETTA, Luigi TRITAPEPE, Luigia SCUDE
    Minerva Anestesiologica.2021;[Epub]     CrossRef
  • Use of Angiotensin II in Severe Vasoplegia After Left Pneumonectomy Requiring Cardiopulmonary Bypass: A Renin Response Analysis
    Brian Trethowan, Christopher J. Michaud, Sarah Fifer
    Critical Care Medicine.2020; 48(10): e912.     CrossRef
  • Renin as a Marker of Tissue-Perfusion and Prognosis in Critically Ill Patients*
    Patrick J. Gleeson, Ilaria Alice Crippa, Wasineenart Mongkolpun, Federica Zama Cavicchi, Tess Van Meerhaeghe, Serge Brimioulle, Fabio Silvio Taccone, Jean-Louis Vincent, Jacques Creteur
    Critical Care Medicine.2019; 47(2): 152.     CrossRef
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